Mutations in a histone regulator protein are linked to both a rare neurodevelopmental disorder and to some cancers, according to a study published in the journal Genes and Development.
Marc Morgan, DPhil, research assistant professor of Biochemistry and Molecular Genetics, was lead author of the study published in the journal Genes and Development.
The protein, PHIP/BRWD2, binds to three different histone modifications that are associated with active gene expression, which explains it's two-sided impact, according to Marc Morgan, DPhil, research assistant professor of Biochemistry and Molecular Genetics and lead author of the study.